Inactivation of tumor-specific CD8+ CTLs by tumor-infiltrating tolerogenic dendritic cells
نویسندگان
چکیده
منابع مشابه
Inactivation of tumor-specific CD8+ CTLs by tumor-infiltrating tolerogenic dendritic cells
Cancer immunosurveillance failure is largely attributed to the insufficient activation of tumor-specific class I major histocompatibility complex (MHC) molecule (MHC-I)-restricted CD8⁺ cytotoxic T lymphocytes (CTLs). DEC-205⁺ dendritic cells (DCs), having the ability to cross-present, can present captured tumor antigens on MHC-I alongside costimulatory molecules, inducing the priming and activa...
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ژورنال
عنوان ژورنال: Immunology and Cell Biology
سال: 2013
ISSN: 0818-9641
DOI: 10.1038/icb.2013.38